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The role of genetic variation in the causation of mental illness: an evolution-informed framework Rudolf Uher. But actually puberty is our second major exposure to these hormones because they were transiently active during fetal life and then inactivated in infancy. There are structural and functional differences between the male and female brain—for example the neural control of hormone secretion is quite different, and so is psychosexual function.

The size of some nuclei in the brain associated with these functions also shows gender differences.

There may be other differences but this is an area where the politics of gender interact with biomedical science. The recent furore at Harvard over the comments of former President Larry Summers,18 who implied that gender differences in brain function extended to other domains, has shown how easy it is for simple biomedical observations to be misused in a sociopolitical arena.

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